Kolloquiumsvortrag (MaWi), Prof. Weller, Uni Hamburg / am 15.01.2018
15.01.2018 von 17:15 bis 18:00
Institute Ostufer, Geb. D, "Aquarium", Kaiserstr. 2, 24143 Kiel
Titel: Nanocrystals in Materials and Life Science Applications
Abstract:
Horst Weller,
Institut für Physikalische Chemie, Universität Hamburg, Fraunhofer-Zentrum für Angewandte Nanotechnologie (CAN), The Hamburg Centre for Ultrafast Imaging (CUI)
Nanocrystals are already used for many applications in technical products for every day life. The talk will describe actual developments such as quantum dots in display and lighting technology and ultra-hard nanocomposite materials. Modern aspects of particle synthesis will be discussed.
The key idea for using nanocrystals for biomedical diagnostics is to benefit from their outstanding physical properties in the visualization of biological events or malignant cells or tissues. This requires a special design of the ligand shell, which preserves the fluorescent, magnetic and plasmonic properties of the particles in the biological environment on one side and allows a specific targeting on the other. The lecture reports on different chemical approaches and describes factors determining the biological response on fully synthetic nanocrystals. We will highlight concepts based on PEGylation and show how small deviations in the ligand shell alter the behavior in biological environment substantially. Moreover, we will present combinatorial approaches for the functionalization of the nanocrystals with biological affinity molecules to improve targeting specificity and concepts to optimize the physical properties of the inorganic core to increase the sensitivity for the respective imaging techniques.