Kolloquiumsvortrag (MAWI), Iain Dunlop, Imperial College London / am 25.06.2018

25.06.2018 von 17:15 bis 18:00

Institute Ostufer, Geb. D, "Aquarium", Kaiserstr. 2, 24143 Kiel

Titel: Engineering the immune system with graphitic nanomaterials

Abstract: Recent work shows that immune cell signalling is controlled by supramolecular assemblies of molecules on the c. 100 nm scale.  This insight offers the possibility of developing new nano-scale reagents to direct immune cell activation. We have used nano-flakes of graphene oxide as templates to develop molecular nanoclusters of monoclonal antibodies (mAb) that stimulate immune cells. This technology is applied to Natural Killer (NK) cells: a key cell type in the body’s natural anti-cancer defences. The nanoclusters successfully activate NK cells, enhancing the potency of the clustered mAb. This demonstrates molecular nanoclustering as a powerful approach to developing new immunomodulatory reagents with graphene oxide -templated nanoclusters a strong candidate technology.

Prof. Selhuber

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